The synthesis of C-13 labeled vitamin E, (12'a,13'-13C)all-rac-.ALPHA.-tocopherol.
نویسندگان
چکیده
منابع مشابه
Synthesis of 13 C - labeled carotenoids and retinoids
A three-part strategy has been developed to study molecular interactions in biological systems at the atomic level. First, isotopically labeled carotenoids and retinoids are prepared by organic total synthetic schemes with labels at predetermined atomic positions and combinations of positions. Subsequently, the labeled compounds are incorporated in the biological system. Finally, the system is ...
متن کاملThe molecular basis of vitamin E retention: structure of human alpha-tocopherol transfer protein.
Alpha-tocopherol transfer protein (alpha-TTP) is a liver protein responsible for the selective retention of alpha-tocopherol from dietary vitamin E, which is a mixture of alpha, beta, gamma, and delta-tocopherols and the corresponding tocotrienols. The alpha-TTP-mediated transfer of alpha-tocopherol into nascent VLDL is the major determinant of plasma alpha-tocopherol levels in humans. Mutation...
متن کاملEffect of DL-alpha-tocopherol (vitamin E) on the differentiation of mouse myeloid leukemia cell.
The effect of DL-alpha-tocopherol on the differentiation of the mouse myeloid leukemia cell line (M1) was investigated using fluorometry. The reliability of the fluorometric determination was verified by the mutual overlapping of the curves of disappearance of the radioactivity recovered as alpha-tocopherol and the loss of its fluorescence. alpha-Tocopherol solubilized into the culture medium w...
متن کاملThe Chemistry of Vitamin E. Iii. Permanganate Oxidation of Alpha Tocopherol.
By oxidizing alpha tocopherol with chromic anhydride in acetic acid solution, a lactone C21H4002 was obtained. The origin of such a lactone is easily explicable on the theory that alpha tocopherol contains a chromane ring; if alpha tocopherol contained a coumarane ring, a beta hydroxy acid would be expected. Karrer and his co-workers,2 by treating pseudo cumo hydroquinone with phytyl bromide, o...
متن کاملSimultaneous determination of homologues of vitamin E and coenzyme Q and products of alpha-tocopherol oxidation.
A sensitive procedure is described for the simultaneous determination of vitamin E and coenzyme Q homologues and alpha-tocopherol oxidation products using two-isocratic step high pressure liquid chromatography (HPLC) and electrochemical detection in the oxidative mode. Zinc-catalyzed reduction in a post-column reactor allows the detection of alpha-tocopherolquinone, epoxy-tocopherolquinone, and...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1985
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.33.1266